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Three edaravone trials in Japan did not initially convince the FDA that the drug was effective, but the agency reconsidered because one of the trials showed a 33 percent slowing of disease progression in a subset of participants

usp.org Full methodology: Methodology & Sources

The microfracture technique for the treatment of full-thickness articular cartilage lesions of the knee: midterm results

As with all procedures and meds used in the practice of medicine, the dose, timing, mixture, and monitoring of symptoms and laboratory tests is crucial to obtain optimal results